Black cohosh – Cimicifuga racemosa
Current use: Menopausal therapy for hot flashes, profuse sweating and vaginal complaints
Active Ingredients: triterpene glycosides, phenolic acids, flavonoids, volatile oils, tannins
Standardization: 2.5% triterpene glycosides
Research: was not statistically significant in treating hot flashes after 16 weeks; does improve the vaginal maturity index in postmenopausal women; approaches significance in treating vaginal dryness; statistically significant in treating anxiety
Mechanism: SERM (does not affect ERα or ERβ but does have an effect on ERϒ), high affinity for various serotonin receptors
Safety: Relatively safe; however, case reports about liver toxicity. Because of unknown MOA and potential estrogenic effect it should be avoided during pregnancy and lactation and in children under 12.
Ginkgo - Ginkgo biloba
Current use: asthma, fatigue, tinnitus, memory improvement
Active Ingredients: flavonol, glycosides, terpene lactones, bilobalide
Standardization: 6% terpene lactone sna 24% flavones glycosides
Research: 300 mg improved physiological sexual arousal but no subjective sexual arousal; when combined with sex therapy increased sexual desire and contentment; effective in alleviating antidepressant-induced sexual symptoms in 84% of cases
Mechanism: Relaxes smooth muscle, facilitates peripheral blood flow, has NO-scavenging abilities
Safety: Side effects are rare and limited to mild, transient and reversible; drug interactions with warfarin, aspirin, lithium; safety in pregnancy and breastfeeding has not been established
Maca – Lepidium meyenii
Current use: Andean aphrodisiac an/or fertility-enhancing, menopausal therapy
Active Ingredients: sterols which possess phytoestrogen activity
Standardization: Unknown
Research: RDBPCT decreased psychological symptoms including anxiety, depression and sexual dysfunction and did not affect estradiol, FSH, LH or SHBG levels.
Mechanism: Unknown
Safety: Unknown
Puncture vine – Tribulus terristris
Current and traditional use: ancient aphrodisiac, UTI treatment, inflammation, edema and TCM sexual dysfunction
Active Ingredients: Steroidal saponins (tribestane, vitanone and protodioscin)
Standardization: 16.4% protodioscin
Research: 49/50 women experienced improvement in all or some menopausal symptoms (hot flashes, depression, genital discomfort, libido) however, may lack validity due to conflict of interest
Mechanism: increase endogenous androgen production by increasing LH release from the pituitary gland; increases NO release
Safety: Phototoxic reactions; safety during pregnancy and lactation has not been established
Red clover – Trifolium pretense
Current use: Menopausal therapy for hot flashes, profuse sweating and vaginal complaints
Active Ingredients: phytoestrogens such as genistein, formononetin, daidzein and biochanin A
Standardization: 9-15% isoflavones
Research: meta-analysis showed a marginal effect for treating hot flashes with 40-82 mg/day; significant beneficial effect on vaginal and sexual health in postmenopausal women
Mechanism: SERM (does not affect ERα or ERβ but does have an effect on ERϒ), high affinity for various serotonin receptors
Safety: Safe and well-tolerated in women with one first degree relative with breast cancer; supplements containing these isoflavones did not adversely affect breast density, skeletal strength or cardiovascular status; none of the CCT have reported adverse effects at doses upt to 160 mg of isoflavones per day.
Chasteberry fruit – Vitex agnus-castus
Current use: Premenstrual syndrome
Active Ingredients: triterpene glycosides, phenolic acids, flavonoids, volatile oils, tannins
Standardization: 0.05% agnuside and 0.08% casticin
Research: topical application - improvement in vaginal tone, thinning and lubrication with less dyspareunia; increased uterine weight, serum progesterone and estrogen levels in ovariectomized female rats; decreased LH and Prolactin
Mechanism: SERM (affects ERα or ERβ), decreases LH and prolactin; dopaminergic D2 receptor agonist; increases melatonin secretion
Safety: Relatively safe
Dong quai – Angelica sinensis
Current use: replenishing the blood, treating menstrual disorders and menopausal symptoms; when used in Traditional Chinese Medicine is used in conjunction with other herbs
Active Ingredients: ferulic acid and Z-ligustilide; has no phytoestrogens.
Standardization: ferulic acid 0.4-0.7%, 0.5-5.0% ligustilide
Research: When used alone has not effect in treating menopausal symptoms; has no estrogenic effect in humans but did in rat studies; when combined with Matricaria chamomilla demonstrated a reduction in hot flashes, improved sleep; when combined with Astragalus membranaceus helped decrease mild hot flashes; the improvement of sexual symptoms was not explored
Mechanism: not mentioned
Safety: few side effects including headache and potentiates anticoagulant therapy; do not use in children or adults with diarrhea, hemorrhagic diseases, hypermenorrhea, pregnancy or lactation; some concerns about liver toxicity
Zalloh – Ferula hermonis
Current use: native to Syria and Lebanon, used as a strong aphrodisiac for both sexes, treatment of frigidity and circulation enhancement
Active Ingredients: ferutinin has binding capacity for estrogen receptor α and β equivalent to about 1/10 of the binding affinity of estradiol
Standardization: not mentioned
Research: may be suggested for female sexual dysfunction associated with desire disorder
Mechanism: estrogenic effect, increased production of progesterone and therefore stimulate female sexual behavior
Safety: Unknown
Hops - Humulus lupulus
Current use: in Germany hops baths are used for treatment of gynecological disorders and hops extracts have been reported to reduce hot flashes in menopausal women
Active Ingredients: 8-prenylanaringenin; isoxanthohumol which can readily be converted to 8-prenylnaringenin by intestinal microbes; three flavonoids with estrogenic activity including: 6-prenylnaringenin, 8-geranylnaringenin and 6,8-diprenylnaringenin
Standardization: 0.11 + 0.01 mg of 8-prenylnaringenin/capsule
Research: RPCCO studies with 50 postmenopausal women over 16 weeks showed superiority over placebo for treating hot flashes; other studies have shown improvement in climacteric symptoms; topical application combined with hyaluronic acid, liposomes and Vitamin E showed significant improvement in vaginal dryness. Animal studies demonstrate an estrogenic effect on the uterus, vagina and mammary gland secretion however in vitro study did not confirm androgenic or progestogenic activity of the active ingredient.
Mechanism: may act as a SERM
Safety: safe alternative treatment for genital atrophy in postmenopausal women when HRT is not recommended; causes drowsiness; inhibits cytochrome P450; unknown safety during pregnancy and nursing.
Reference: J Sex Med 2010;7:3695-3714